The Range in Croydon has now opened on the Purley Way.
The store took over the former Homebase site, which closed in September.
The mayor of Croydon, Bernadette Khan, was on hand to officially open the value home, leisure and garden chain.
More than 80 jobs have been created at the Croydon store, including full and part-time roles.
Founder, Chris Dawson was pleased to be opening a shop in Croydon, he said: “This site has been on the radar for some time and we are delighted to replace the former Homebase with a new national retailer in the town.
“We are very lucky with the staff we have, and I look forward to welcoming the new team members to the company.”
(Image: Grant Melton, Croydon Advertiser)